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 What about topical ways to create the Ultimate ATP Environment?
Some of the most forward thinking age defying ingredients on the market today contain ATP and mitochondrion activity at the forefront of their formulations. Unichondrin ATP (Adenosine Triphosphate) One of the hottest new ingredients is Unichondrin ATP, which is adenosine triphosphate itself! When formulated in a cosmetic, it acts as a biocatalyst that stimulates cellular metabolism and greatly stimulates fibroblast activity, assisting in the assertive formation of the extra cellular matrix of the connective tissue. This action greatly firms and plumps the skin allowing for fast acting, long lasting age defying results.
ATP is also one if the strongest new ingredients that greatly assists with moisture retention comparable, and also unique, to that of hyaluronic acid. ATP greatly assists the hydrating properties of chondroitin sulfate and also does an amazing job of stabilizing and energizing existing ATP. ATP immediately improves the visual appearance and texture of the skin that can be felt and seen, smoothing fine lines and wrinkles.
Efficacy studies performed with this ingredient confirmed a 62% increase in moisture of the skin after four weeks of use, and more than a 42% reduction of wrinkles and wrinkle intensity. ATP Synthesis Studies indicate that a healthy human body will use what is equivalent to their body weight in ATP every day. And by the time that they have reached the age of 60, this production will have deteriorated by nearly half. This fact certainly drives home the saying that when we age we simply run out of energy; it is a fact! Thiotaine (Ergothioneine) Ergothioneine is an amino acid found in mushrooms and wheat germ and is another hot ingredient for cosmetic products today because it plays four major roles in the skin:
1) Ergothioneine ensures higher levels of cellular energy. Energy is produced within cells by mitochondria - microscopic bodies responsible for producing over 90% of the body’s energy production. Fatty acids and oxygen are paired within mitochondria to produce the fuel molecule ATP (adenosine triphosphate). By speeding the delivery of fatty acids into the mitochondria, ergothioneine ramps up ATP production, making the fuel molecule more available to all parts of the cell. When energy levels go up, cells increase their production of lipids in the epidermis, resulting in softer skin that is more resistant to irritation. At the same time, youthful collagen, elastin and other dermal tissue also become more plentiful, visibly reducing lines, wrinkles and pore size while adding to skin’s underlying firmness. These results can begin to be seen in as little as 24 hours of applying ergothioneine to the skin’s surface.
2) Ergothioneine is a unique antioxidant that protects mitochondria from free radicals. Researchers studying the biochemistry of aging now believe the process begins within mitochondria when these cellular bodies process oxygen into ATP. Ergothioneine protects the structures within mitochondria from attack by oxygen radicals that are created when ATP is produced. So important is the interaction of mitochondria and ergothioneine to sustaining life, mitochondria have developed special ducts in their protective walls dedicated to receiving only ergotheioneine. In various laboratory tests comparing ergothioneine to popular antioxidants, ergothioneine consistently performs better than members of the vitamin C family, CoEnzyme Q10, idebenone, and green and white teas - not just within mitochondria, but throughout the skin.
3) Ergothioneine inhibits the aging effects of glycation. A natural process whereby sugars bind with collagen and other proteins, glycation causes collagen fibers to stiffen, leading to a loss of skin firmness and increased wrinkling. Ergothioneine is an effective glycation inhibitor, partially due to its extensive antioxidant activity.
4) Ergothioneine brightens and clarifies the skin’s color. It is a powerful copper chelator and scavenger of hydroxyl radicals; free radicals that have been linked to inflammation and post inflammatory hyperpigmentation. Ergothioneine noticeably inhibits the formation of melanin. Mitostime (Laminaria Digitata) Mitostime, another mitochondria-specific ingredient, is referred to as the fountain of youth as it increases mitochondrial and basal layer cellular respiration (the capacity for oxygen uptake) by as much as 17%, providing the perfect environment for ATP synthesis and cellular function.
Clinical studies showed that Mitostime significantly improves the condition of the fibroblast activity and function, improves the skin’s ability to recover from external environmental damage, improves protein synthesis activity, and acts as a “defender” of mitochondrial DNA equating to a significantly higher rate of ATP synthesis and NADH Hydrogenase. The results are a younger, more youthful appearance with clinical evidence supporting a 37% increase in collagen synthesis. SYN-TACKS (Glycerin, Palmitoyle Dipeptide – 5/Palmitoyle Dipeptide – 6) SYN-TACKS is the combination of two strategic peptides that have proven to interact with the protein structures of the dermal-epidermal junction (DEJ). Clinical studies indicate that this key ingredient stimulates Laminin V, Collagen type IV, VII, and XVII, and Integrin, simultaneously. Because of this broad spectrum of activity, rapid, visible results can be achieved with clinical studies indicating a 32% improvement of tonicity, 62% improvement of anisotropy, and a 23% increase in cellular cohesion in a two month period of time. Activity and reaction require energy: ATP. Therefore, an ATP rich environment will maximize the benefit and potential of this ingredient. Roxisomes (Arbidopsis Extract) As we age, the ability to replenish and repair the antioxidant capacity of our skin gradually diminishes, which is believed to be amongst the primary factors in aging. This cutting edge ingredient has been proven to repair DNA damage that occurs from oxygen radicals found within environmental pollution and from reactive oxygen species generated by UVA sunlight. Remember also that oxygen radicals are inevitable as the mitochondria generates ATP; our vital cellular energy. As vital as ATP is for our cellular health, arbidopsis extract is vital to ensure cellular balance and homeostasis. Clinical studies indicate that this key ingredient shortens the DNA repair time from 24 hours to 2 hours, and repairs 75% of the oxidative damage on DNA in the mitochondria. Phytoquintescine (Einkorn - Triticom Moncoccum) Quintescine is a dipeptide (Cys-Gly) whose structure is very close to glutathione, a natural tripeptide (Gly-Glu-Cys), both having similar assertive cellular antioxidant properties.
Similar to arbidopsis extract, Quintescine assertively reduces the level of reactive oxygen species (ROS) that are a result of environmental pollution, UVA sunlight and smoking (both which lead to oxidative stress), DNA damage, and ultimately aging skin. Clincial studies indicate that Quintescine increases Cu/Zn SOD expressions (super oxide dismutases) by 146% and catalase expressions by 36%; both expressions are vital for defense against oxidative stress.
Because of the strong benefits and efficacy, Quintescine is a must have ingredient for optimum cellular health and smooth youthful skin. Studies also indicate that Quintescine helps to minimize inflammation, another known key factor of aging skin
A natural active ingredient (yeast extract) trade named Vitacell has been touted as the cell revitalizing factor as it regenerates epidermal energy; ATP. As the skin is a living tissue made of highly developed eukaryotic type cells containing many mitochondria, it requires maximum ATP production to remain vibrant, healthy and youthful. Studies performed with Vitacell established a 57.7% increase in respiration/oxygen consumption allowing for healthier more resilient skin and as much as a 65% increase of ATP synthesis. Additionally, Vitacell was proven to enhance cellular metabolism and cellular function.
Vitacell’s primary mechanisms of action are related to its ability to reduce oxygen into H2O to form a proton gradient in the mitochondrial inner membrane causing ATP–synthetase, which in turn produces ATP.
Biodynes O3 (Saccharomyces Ferment Filtrate Lysate) Biodynes O3 is a yeast extract that offers applied defenses against ozone damage, which is a well defined mechanism of cellular aging, as ozone inherently oxidizes guanine nucleic acids into 8 – oxyguanine. Clinical studies were performed to establish the amount of ozone that the epidermis and skin cells are exposed to within an eight hour day, and that Biodynes O3 was able to reverse the oxidative effects of ozone giving the skin cells complete mitochondrial DNA and RNA damage protection.
Ozone has also been proven to have a degenerative effect on the lipid barrier of the skin. Biodynes O3 has not only been proven to protect against the effects of this degeneration, but also enhance the synthesis of epidermal cholesterol which has been proven to enhance barrier function, crucial to maintaining optimum cellular health and a youthful appearance.
ATP: Current of Life ATP is a subject that you will never stop hearing about; it is healthy, it is youth, it is life. Whether you are 17 or 70, we all need it to survive, maintain optimum health, maintain the youngest looking skin and body possible, and of course to perform any and every function in life. Although there are many other supplements, technology, topicals and foods focused on health, wellness, and youth, keep your eye on the epicenter of life; ATP. Without the current of life, all else is a moot point!
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